The evil Dogs of Plague, disciples of the Great Hound of Hell, plan to kill Monkey, Pigsy, Sandy and Tripitaka. Their leader brings the Plague of Black Dog to a nearby town. The pilgrims arrive at the town, but when Tripitaka tries to help the sick, he catches the deadly plague himself. Monkey discovers the only cure is to give the afflicted grilled fresh monkey brains from a newly dead ape. Will Monkey give up his life to save Tripitaka?